Her name was given to the Mona Lisa, her portrait commissioned by her husband and painted by Leonardo da Vinci during the Italian Renaissance.
Little is known about Lisa's life.
Born in Florence and married in her teens to a cloth and silk merchant who later became a local official, she was a mother to five children and led what is thought to have been a comfortable and ordinary middle-class life.
Lisa outlived her husband, who was considerably her senior.
Centuries after Lisa's death, the Mona Lisa became the world's most famous painting and took on a life separate from Lisa, the woman.
Speculation by scholars and hobbyists made the work of art a globally recognized icon and an object of commercialization.
In 2005, Lisa was definitively identified as the model for the Mona Lisa.