Wu Shu-chen (Chinese: ???; pinyin: Wú Shuzhen; Pe?h-oe-ji: Ngô Siok-tin; born 11 July 1953 in Tainan County, Taiwan) is a Taiwanese politician.
She served one term in the Legislative Yuan from 1987 to 1990.
As the wife of President Chen Shui-bian, Wu was the First Lady of the Republic of China from 2000 to 2008.
She is the only First Lady of Taiwan to have been charged and convicted of a crime; she was sentenced to a one-year prison term for perjury regarding political corruption during her husband's tenure as President.
Her sentence has however been increased to 17 and a half years, same as her husband.