Tokugawa Mitsusada (?? ??, January 28, 1627 – September 25, 1705) was a daimyo in Japan during the Edo period (1603–1868).
Mitsusada born as son and heir of Tokugawa Yorinobu and a grandson of Tokugawa Ieyasu with childhood name Nagatomimaru (???).
Among his sons was the eighth Tokugawa shogun Yoshimune.
Norihime, daughter of his married Ichijo Kaneteru.
He married daughter of Prince Fushimi-no-Miya Sadakiyo, Yaso-no-Miya Teruko (who also sister of Asa no Miya Akiko who was 4th shogun, Tokugawa Ietsuna's wife).
One of the gosanke, Mitsusada ruled the Wakayama Domain from its castle, his birthplace, in Wakayama.
He reached the Junior Second court rank while alive, and was awarded the Junior First rank posthumously; he also held the ceremonial post of gon-dainagon.
His grave is at Choho-ji in Wakayama.
His another sons was Tokugawa Tsunanori (1665-1705) and Tokugawa Yoritomo (1680-1705).