Nijo Akizane (?? ??, December 2, 1556 – August 23, 1619), son of regent Nijo Haruyoshi, was a Japanese kugyo (court noble) of the Azuchi–Momoyama period and the early Edo period.
He held the regent position of kanpaku two times: once in 1585, and again from 1615 to 1619.
He married a daughter of daimyo Oda Nobunaga and the couple adopted Kujo Yukiie's son, who became known as Nijo Yasumichi.