John Spafford Harris (December 18, 1825 – January 25, 1906) was an American politician for the state of Louisiana and member of the Republican Party.
Born to a farm family in Truxton, New York, Harris was a delegate to the Louisiana state constitutional convention in 1868.
He was a member of Louisiana State Senate in 1868 and the first Republican U.S.
Senator from Louisiana, having served from 1868 to 1871.
Harris was buried at Forestvale Cemetery in Helena, Montana.