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About Phillip Thomas Hawkins
- Phillip (Phill) Thomas Hawkins FRS (born 5 October 1958) is a molecular biologist, senior group leader at the Babraham Institute. Phill Hawkins has contributed much to the understanding of inositol lipids functions in eukaryotic cells.
- Together with his long-time collaborator Leonard R Stephens, he established that PtdIns(4,5)P2 is the main substrate of receptor-controlled Type 1 phosphoinositide 3-kinases (PI3Ks), thus identifying PtdIns(3,4,5)P3 as the key output signal produced by this enzyme. They identified and isolated the GPCR-activated Type 1B PI3K (PI3K?) and, in a sustained body of work, defined its structure, explained its complex pattern of regulation by GĂ? and Ras, and proved its role in inflammatory events in vivo.
- They - in parallel with Dario Alessi - identified phosphoinositide-dependent kinase-1 as the PtdIns(3,4,5)P3-activated link between PI3K-1 activation and protein kinase B activation, a key pathway through which PtdIns(3,4,5)P3 formation regulates cell proliferation and survival.
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