She was married to the nineteenth century geologist Roderick Impey Murchison.
Several times during her life the couple traveled throughout continental Europe visiting places such as France, the Alps, and Italy.
She also created numerous sketches of geological features, such as cliffs and fossils, in England during their numerous excursions throughout the country, including the Yorkshire coast in 1826.
Throughout her life and their travels, she did significant work in collecting fossils, and, having been taught by Paul Sandby, she created geological sketches of important features.
With many of her sketches she often did not focus on the geological features in detail, but instead created a more emotive illustration of the landscape.
Through her work she also helped her husband to develop many of his publications.
Many of her illustrations, such as "Valley of Gosau" were incorporated into works her husband published.
Charlotte is also often credited for being a significant influence on her husband’s career.
Unfortunately, on one of the trips she took with her husband she contracted malaria and faced complications throughout the rest of her life until it finally claimed her life.Charlotte Murchison died on 9 February 1869 at Belgrave Square, London.