He is best known for creating The Adventures of Tintin, the series of comic albums which are considered one of the most popular European comics of the 20th century.
He was also responsible for two other well-known series, Quick & Flupke (1930–1940) and The Adventures of Jo, Zette and Jocko (1936–1957).
Working for the conservative Catholic newspaper Le Vingtième Siècle, he created The Adventures of Tintin in 1929 on the advice of its editor Norbert Wallez.
Revolving around the actions of boy reporter Tintin and his dog Snowy, the series' early installments — Tintin in the Land of the Soviets, Tintin in the Congo, and Tintin in America — were designed as conservative propaganda for children.