She returned from 1993–97, and again in 1999.
Frame was plain and a victim of sexual abuse and multiple personality disorder, but Holbrook proved she could portray her convincingly.
She was subsequently paired with David Forsyth.
She won a Daytime Emmy Award for Outstanding Supporting Actress award for her role as Sharlene in 1996.Holbrook has appeared in numerous guest starring roles on Law & Order and Law & Order: Special Victims Unit.
She appeared in the film I Love Trouble, which starred with Nick Nolte.
She has also appeared in off-Broadway and regional theater.