Mary of Guise (French: Marie de Guise; 22 November 1515 – 11 June 1560), also called Mary of Lorraine, ruled Scotland as regent from 1554 until her death.
A noblewoman from the Lotharingian House of Guise, which played a prominent role in 16th-century French politics, Mary became queen consort upon her marriage to King James V of Scotland in 1538.
Her infant daughter, Mary, ascended the throne when James died in 1542.
Mary of Guise's main goal as regent was a close alliance between the powerful French Catholic nation and smaller Scotland, which she wanted to be Catholic and independent of England.
She was ultimately unable to prevent the Protestant Reformation in Scotland, which after her death left her daughter in a precarious position.