After attending primary school in his native village, he went on to high school in Bucharest, Calara?i and Odorhei.
Acsinteanu attended the faculties of literature and law at the University of Bucharest and Cernau?i University.
His first published work appeared in Ritmul vremii; other contributions were published in Falanga, Universul literar, Gândirea, Vremea, Convorbiri Literare, Clipa, Universul, Diminea?a, Cultura poporului, ?ara noastra, Ecoul and Orizonturi.He headed Pan magazine and, from 1926 to 1930, was secretary of the literary circle affiliated with the Institute of Literature and Bibliography led by Mihail Dragomirescu.
Acsinteanu was a proofreader for Chemarea and Facla and editing secretary at Ilustra?iunea româna.
His first novel, prefaced by Liviu Rebreanu, was Piatra neagra (1930); there followed Povestiri pentru îngerii pamântului, 1932; Convoiul flamânzilor, 1935; Prin?ul Baraganului, 1935; Copilul norilor, 1936; and Escadrila alba, 1937.Acsinteanu led an unsettled life, working jobs that were often completely unrelated: tinker's apprentice, typographer, teacher, librarian, editor at ?ara noastra, literary secretary at Romanian Radio, servant at a tavern in Calara?i.
After the King Michael Coup of 1944, the pattern continued: cowherd, technical adviser at a state collective farm and legal adviser in Tulcea and Cernavoda.