H.M.Cassime (born Mohamed Cassime also spelt as Mouhamad Cassime, H.M.Kassim) (Tamil: ???.???.??????) (1900–1986) was a Tamil-born businessman and Mayor of Pondicherry.
He served as Mayor from 15 September 1956 to 3 November 1961 during the period of the merger of Pondicherry from French India to the Republic of India.