Takatsukasa Masahiro (?? ??, May 14, 1761 – March 29, 1841), son of regent Sukehira, was a Kugyo or Japanese court noble of the Edo period (1603–1868).
He held a regent position kampaku from 1795-1814.
Masahiro's son, Masamichi, was born to a daughter of the eleventh head of Tokushima Domain, Hachisuka Shigeyoshi.