Melville "Mel" Spence (2 January 1936 – 28 October 2012) was a Jamaican sprinter who competed in the 1956 Summer Olympics and in the 1964 Summer Olympics.
He is the twin brother of Mal Spence, an Olympic sprint medalist.He was a relay silver medalist at the 1955 Pan American Games and was runner-up in the individual 400 m event at the 1963 Pan American Games.
He was part of the winning Jamaican 4×400 metres relay team at the 1962 Central American and Caribbean Games.