Marin taught at the University of Nanterre, Paris from 1967 to 1970, the University of California, San Diego from 1970 to 1974, Johns Hopkins University from 1974 to 1977, and finally at the École des Hautes Études en Sciences Sociales in Paris from 1977 to 1992.
He was also an Associate of the Humanities Center at Johns Hopkins University from 1985 until his death in 1992 in Paris.
Marin was widely known for his work in a variety of areas: linguistics, semiotics, theology, philosophy, anthropology, rhetoric, art and institutional history and literary theory.
Throughout his career, Marin's main intellectual focus was seventeenth-century French literature and art, particularly the works of Blaise Pascal, Perrault, Nicolas Poussin and Philippe de Champaigne.
In addition, he published numerous articles on the visual arts and religious texts.