Espen Isaksen (born 16 January 1979, in Narvik) is a Norwegian football goalkeeper.
He started his top-level career with Rosenborg BK, but did not make a single league appearance and moved to Byåsen IL, where he spent a season and then played for 2 years for amateur side Oslo Øst.
In 2004, he was signed by Stabæk Fotball, but only made 1 league appearance in 2 years he joined Odd Grenland.
He retired after the 2008-season and is now the keeper coach for Tromsø IL.
He later served as reserve goalkeeper.
Isaksen was brought in for one game for Stabæk, because they had no keeper available for the game.