Vilakazi (May 18, 1943 in Nongoma–January 26, 2016 in Pretoria) was a South African sociologist.
He was known for his opposition to South Africa's apartheid system, which motivated him to try to dismantle it from the inside by becoming a professor at the University of Transkei, despite the protests of the African National Congress.
He was also a prominent critic of Western medicine, and promoted ubhejane as a treatment for HIV/AIDS.