He had a brief stint in Extreme Championship Wrestling (ECW) in 1995, before he signed with World Championship Wrestling (WCW).
In WCW, Mysterio helped popularize the high-flying lucha libre wrestling style, which is credited with having also helped kick-start the emergence of cruiserweight wrestling in the United States.
He also won a number of championships during his time with the company, including the WCW Cruiserweight Championship and the WCW World Tag Team Championship.
After WCW closed in 2001, Mysterio returned to Mexico, briefly wrestling for Consejo Mundial de Lucha Libre (CMLL), before signing with WWE in 2002.
Over the course of his time with the company, he has achieved sustained success, and is a two-time Intercontinental champion, two-time United States Champion, a four-time tag-team champion, a three-time Cruiserweight champion, and a three-time world champion.
He is also the winner of the 2006 Royal Rumble and has headlined several major WWE pay-per-view events.
He departed the company in 2015 and then wrestled on the independent circuit, before returning to WWE in 2018.
Per WWE, Mysterio is one of the most well-known and revered performers of all time.