Luise von Degenfeld (28 November 1634 – 18 March 1677) was the morganatic second wife of Charles I Louis, Elector Palatine.
Born Maria Susanne Luise von Degenfeld in Strasbourg, she was the daughter of an impoverished baron, Martens-Christof von Degenfeld and his wife, Maria Anna Adelmann von Adelmannsfelden.
In 1650 she was appointed a lady-in-waiting at the Electoral Palace at Heidelberg to Charlotte of Hesse-Kassel, the consort of Charles I Louis, Elector Palatine.
He was the son and heir of Frederick V, the "Winter King" of Bohemia, by Elizabeth Stuart, daughter of James I of England.