He directed ten plays as well including Sexo, pudor y lágrimas, which he also wrote.
He made this play into a film in 1999 which became the highest grossing at the time (Mex$118,000,000, or 12 million US dollars at the exchange rate of 1999).
The movie was seen exhibited for six months by millions and earned several Ariels awarded by the Mexican Academy of Film.
His following films were Lucia, Lucia with All About My Mother Argentine actress Cecilia Roth and the segment El TorzĂłn of the series of short-films about violence in Mexico City titled Cero y van cuatro.
Serrano was nominated for the Ariel Award in 2004 for his adaptation of the script of LucĂa, LucĂa.