Anastasio Aquino's Rebellion was an uprising led by Salvadoran indigenous leader Anastasio Aquino (April 15, 1792, Santiago Nonualco, El Salvador – July 24, 1833, San Vicente, El Salvador) in El Salvador during the time it belonged to the Federal Republic of Central America.
Aquino was born into a family belonging to the Taytes (chiefs) of the Nonualco, an Indigenous tribe of the Pipil nation that occupied the territory of the current Department of La Paz.