She served as hovfröken (maid of honour) to the queen dowager Josephine in 1865-67.
Lotten Edholm initiated the participation of women in Sweden in the Swedish Red Cross and served as chair of the women's section of the Swedish Red Cross in 1865-1906.
She also started a cooking school in Stockholm.
Lotten Edholm was also active as a composer and composed piano music for private use in high society life.
In 1919, she published her memoirs, Från barndom till ålderdom (From Childhood to Old Age).