Hedwig of Munsterberg-Oels (Czech: Hedvika Minstrberská; 10/12 June 1508, Olesnica – 28 November 1531, Legnica) was born Duchess of Münsterberg and Olesnica and Countess of Kladsko and by marriage Margravine of Brandenburg-Ansbach-Kulmbach.
Hedwig was a daughter of Duke Charles I of Münsterberg-Oels, who was a grandson of the King George of Bohemia.
Her mother was Anna of Sagan, a daughter of John II, the last Duke of Zagan (Sagan).
On 9 January 1525 Hedwig married Margrave George of Brandenburg-Ansbach-Kulmbach.
She was George's second wife.
The marriage produced two daughters:
Anna Maria (1526–1589) married in 1544 Duke Christoph of Württemberg (1515–1568)
Sabina (1529–1575) married in 1548 Elector Johann Georg of Brandenburg (1525–1598)Hedwig died in Legnica (Liegnitz), where she was buried.