She has in the past been the Bloc's critic of Human Resources Development and of Industry, and of Foreign Affairs.
In June 2005, Lalonde introduced in Parliament a private Bill C-407 that would have legalized assisted suicide in Canada.
Re-elected in January 2006, she promised to reintroduce her bill to legalize assisted suicide.
On September 13, 2010, Lalonde announced she would not be a candidate for re-election following the expiration of her current mandate "because of the re-emergence of my cancer and the need to pursue new treatments".