Eric J. Nestler, Date of Birth
TweetEric J. Nestler
Professor of Neuroscience
Date of Birth: 08-Jul-1954
Profession: neuroscientist
Nationality: United States
Zodiac Sign: Cancer 
About Eric J. Nestler
- Eric J.
- Nestler is the Dean for Academic and Scientific Affairs and Director of the Friedman Brain Institute at the Icahn School of Medicine at Mount Sinai in New York.
- His focus in neuropsychopharmacology concentrates on forming a molecular approach to psychiatry and furthering the understanding of the molecular basis of both depression and drug addiction, using animal models to study the way drug use or stress affects the brain.
- His addiction research largely centers around several transcription factors, including ?FosB and CREB (master control proteins that induces addiction or depression in vulnerable individuals or resistance to these syndromes in resilient individuals) and the associated epigenetic remodeling that occurs in specific neuronal cell types in the brain.
- Among the prominent targets of this work are medium spiny neurons of the nucleus accumbens and pyramidal neurons in prefrontal cortex and ventral hippocampus.[3][4][5] The Nestler laboratory has driven innovative use of viral-mediated gene transfer, inducible, cell-type specific mutations in mice, and locus-specific epigenome editing to establish causal links between molecular and behavioral phenomena in animal models.[4][6][7].Nestler is the author (with Dennis S.
- Charney) of Neurobiology of Mental Illness (ISBN 0195189809), of Molecular Neuropharmacology (with Steven E.
- Hyman and Robert C.
- Malenka; ISBN 978-0-07-148127-4), and more than 650 chapters and peer-reviewed publications.
- He directs five research projects funded by the National Institute on Drug Abuse and the National Institute of Mental Health.
- He also serves as director of the Depression Task Force of the Hope for Depression Research Foundation.
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