In 2015, Powell founded Rythmia Life Advancement Center in Costa Rica, after an experience with plant medicine helped him overcome depression.
The medically-licensed luxury retreat center focuses on spiritual awakening and facilitates plant medicine journeys.Powell also founded Y-Rent, which was designed to help consumers buy homes with no down payment and low monthly payments.
In 1994, he co-founded Cooperative Images Inc., which became ThatLook.com.
The company went public in 1999.
He later founded My Choice Medical, which was sold in 2004 for $94 million.
He also founded Truthenomics, an online program that teaches manifestation skills.