In 2018, he released "Bipolar", along with Ozuna and Chris Jeday.
The single was a success, and peaked at No.
17 on the Billboard Hot Latin Songs chart.In 2018, Brytiago released "Asesina" with Darell.
Following the release of the remix featuring Daddy Yankee, Anuel AA, and Ozuna, it would become his first top ten on the Billboard Hot Latin Songs chart.In February 2019, Brytiago collaborated with Anuel AA for the song "Controla."