Date of Birth: 
About Hans Lineweaver
- Hans Lineweaver (December 25, 1907 – June 10, 2009) was an American physical chemist, who reinvented the Lineweaver–Burk plot.
- The paper containing the equation, also known as the Double Reciprocal Plot, was co-authored by Dr.
- Dean Burk, and was entitled "The Determination of Enzyme Dissociation Constants (1934)".
- It remains the most frequently cited paper to appear in the Journal of the American Chemical Society.Linearizations of the Henri-Michaelis-Menten law of enzyme kinetics were important in the era before general availability of computers to determine the parameters Vmax and Km from experimental data, even though there are significant statistical problems involved in this procedure.
- These are still used for data presentation.
- All three possible methods of linearization (now called Lineweaver-Burk, Eadie-Hofstee and Hanes plots, respectively) were originally proposed by Woolf, who was unable to formally publish them due to injuries received in a car accident.
- However, he had discussed them with his close friend and fellow member of the British Communist Party, J.
- B.
- S.
- Haldane, who referred to them in his seminal book on enzyme kinetics.
- However, the linearizations were largely ignored until they were re-invented by the authors whose name they now bear.Lineweaver developed the Lineweaver–Burk equation in 1934 while still a graduate student, working as a laboratory assistant under Burk at the U.S.
- Department of Agriculture in Washington, D.C.
- He is an internationally recognized authority on food technology as it is applied to the processing, preservation and safety of poultry and eggs.
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