She is a Regents' Professor of Astronomy and associate department head at the University of Arizona.
Rieke is the Principal Investigator on the near-infrared camera (NIRCam) for the James Webb Space Telescope (JWST).
She has also served as the deputy-Principal Investigator on the Near Infrared Camera and Multi-Object Spectrometer (NICMOS) for the Hubble Space Telescope (HST), and as the co-investigator for the multiband imaging photometer on the Spitzer Space Telescope, where she also acted as an outreach coordinator and a member of the Science Working Group.
Rieke was also involved with several infrared ground-based observatories, including the MMT Observatory in Arizona.
She was co-vice chair of the Astro2010 Decadal Survey Committee for the Astronomy and Astrophysics Decadal Survey.
Marcia Rieke is considered by many to be one of the "founding mothers" of infrared astronomy, along with Judith Pipher.