Emmanuel of Anhalt-Köthen (Plötzkau, 6 October 1631 – Köthen, 8 November 1670), was a German prince of the House of Ascania and ruler of the principality of Anhalt-Plötzkau.
From 1665, he was ruler of the principality of Anhalt-Köthen.
He was the third and youngest son of Augustus, Prince of Anhalt-Plötzkau, by his wife Sibylle, daughter of John George I, Count of Solms-Laubach.