Susan Charlotte Catherine, Lady Adolphus Vane-Tempest (7 April 1839 – 6 September 1875), born Lady Susan Charlotte Catherine Pelham-Clinton, was a British noblewoman and one of the mistresses of King Edward VII of England when he was Prince of Wales.
Lady Susan was a bridesmaid to Victoria, Princess Royal and two years later became the wife of Lord Adolphus Vane-Tempest.
She took the Prince as her lover in about 1864 following her husband's death, and allegedly gave birth to his illegitimate child in 1871.