Prince Shimazu Hisamitsu (?? ??, November 28, 1817 – December 6, 1887), also known as Shimazu Saburo (?? ??), was a Japanese samurai of the late Edo period.
The younger brother of Shimazu Nariakira, Hisamitsu served as regent for his underage son Tadayoshi, who became the 12th and last daimyo of Satsuma Domain.
Hisamitsu was instrumental in the efforts of the southern Satsuma, Choshu, and Tosa clans to bring down the Tokugawa Shogunate.
Hisamitsu held the court title of Osumi no Kami (???).