In 1917 he married Marthe Momont, grandniece of Emile Roux.
During the 1920s, Ramon, along with P.
Descombey, made major contributions to the development of effective vaccines for both diphtheria and tetanus.
In particular, he developed a method for inactivating the diphtheria toxin and the tetanus toxin using formaldehyde which, in its essentials, is still used in vaccines manufactured today.
He also developed a method for determining the potency of the vaccines, an essential element required for the reproducible production of these pharmaceuticals.
He received 155 Nobel Prize Nominations but never received the prize.A collection of his papers is held at the National Library of Medicine in Bethesda, Maryland.