In order to supplement his income, he sold wine and liquor.
He served as a doctor in the Costa Rican army during the invasion of William Walker in 1856.
He died of typhoid in Puntarenas.
Hoffmann is commemorated in the names of a number of animals, including Hoffmann's two-toed sloth (Choloepus hoffmanni ), Hoffmann's woodpecker (Melanerpes hoffmannii ), the sulphur-winged parakeet (Pyrrhura hoffmanni ), Hoffmann's antthrush (Formicarius hoffmanni ), Hoffmann's earth snake (Geophis hoffmanni ), and a millipede Chondrodesmus hoffmanni (Peters, 1864).