Randolph Jefferson (October 1, 1755 – August 7, 1815) was the younger brother of Thomas Jefferson and a planter.
He was Thomas' only brother to survive infancy.
He was a twin to Anna Scott Jefferson, Thomas' youngest sister.
Randolph and Anna were 12 years younger than Thomas.
He married his first cousin, Anne Lewis, on 30 July 1781 in Albemarle County.
They had five sons and a daughter who survived.
They resided at Snowden in Buckingham County.
Anne died some time after the birth of their last son in 1796-97, and before Randolph's May 1808 will.
Randolph remarried after May 1808 and before December 1809 to Mitchie B.
Pryor of Buckingham County.
She conceived a son before Randolph died in August 1815.