George III, Prince of Anhalt-Dessau (Dessau, 15 August 1507 – Dessau, 17 October 1553), was a German prince of the House of Ascania and ruler of the principality of Anhalt-Dessau, and also a Protestant Reformer.
After 1544 he became the first ruler of the principality of Anhalt-Plötzkau.
George was the third (but second surviving) son of Ernest I, Prince of Anhalt-Dessau, by his wife Margarete, daughter of Henry I, Duke of MĂĽnsterberg-Oels and granddaughter of George of Podebrady, King of Bohemia.