Colonel William Preston (December 25, 1729 – June 28, 1783) played a crucial role in surveying and developing the colonies going westward, exerted great influence in the colonial affairs of his time, ran a large plantation, and founded a dynasty whose progeny would supply leaders for the South for nearly a century.
He served in the Virginia House of Burgesses, and was a Colonel in the militia during the American Revolutionary War.
He was one of the thirteen signers of the Fincastle Resolutions, a predecessor to the United States Declaration of Independence.He was a founding trustee of Liberty Hall (later Washington and Lee University), when it was made into a college in 1776.