Tupua Tamasese Mea'ole (June 3, 1905 – April 5, 1963) was a Western Samoan chief.
He held the position of Tupua Tamasese from 1929 to 1963, and O le Ao o le Malo (Head of State) jointly with Malietoa Tanumafili II from 1962 until his death the following year.