Not to be confused with Margaret Paleologa (1364–1420)Margaret Palaeologa (Italian: Margherita Paleologa; 11 August 1510 in Casale Monferrato – 28 December 1566 in Mantua), was an Italian ruler; ruling Marchioness of Montferrat in 1533 - 1536.
She was also Duchess of Mantua by marriage to Federico II, Duke of Mantua.
Margaret was the regent of Mantua as the guardian of her two sons from 1540 until 1556 in companionship with her brother-in-law.