He also was Government Spokesman from June 2007 to March 2008 as Minister of State under the Prime Minister.
He was elected as 2nd Vice President of ORU Fogar at the organization's General Assembly held in Quito (Ecuador) on 16 October 2016.
On 10 December 2017, Wauquiez was elected president of The Republicans by a wide margin.
Pundits have described him as moving the party to the right.On 2 June 2019, a week after overseeing the worst result for the right in its history in the European elections with 8.48% of the vote, Wauquiez announced his resignation as president of The Republicans.