Frederick of Anhalt-Harzgerode (16 November 1613, Ensdorf, Bavaria – 30 June 1670, Plötzkau), was a German prince of the House of Ascania and the first ruler of the principality of Anhalt-Harzgerode.
He was the fourth (but third surviving son) of Christian I, Prince of Anhalt-Bernburg, by his wife Anna of Bentheim-Tecklenburg, daughter of Arnold III, Count of Bentheim-Steinfurt-Tecklenburg-Limburg.
In fact, he was the youngest son of his parents who survived into adulthood: his younger brother, Frederick Louis, born in 1619, died in infancy.